Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells.
Following PTH treatment, immediate changes in osteoblast gene expression involve induction of primary response genes. Primary gene products subsequently mediate the osteoblast response to PTH. Using representational difference analysis (RDA) to isolate primary genes induced by PTH in osteoblasts, we identified Nurr1, a member of the NGFI-B nuclear orphan receptor subfamily. Nurr1 binds DNA as a...
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متن کاملMultiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1
The orphan nuclear receptor nurr1 (NR4A2) is an essential transcription factor for the acquisition and maintenance of the phenotype of dopamine (DA)-synthesizing neurons in the mesencephalon. Although structurally related to ligand-regulated nuclear receptors, nurr1 is functionally atypical due to its inability to bind a cognate ligand and to activate transcription following canonical nuclear r...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2014
ISSN: 0085-2538
DOI: 10.1038/ki.2014.215